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Harris Lab Publications

2015-present

  • Harris KM, Hubbard DD, Kuwajima M, Abraham WC, Bourne JN, Bowden JB, Haessly A, Mendenhall JM, Parker PH, Shi B, Spacek J (2022) Dendritic Spine Density Scales with Microtubule Number in Rat Hippocampal Dendrites. Neuroscience, 489: 84-97. PMCID: PMC9038701. (PDF)
     
  • Jung JH, Kirk LM, Bourne JN, Harris KM (2021) Shortened tethering filaments stabilize presynaptic vesicles in support of elevated release probability during LTP in rat hippocampus. PNAS, 118 (17):e2018653118. (PDF)
     
  • Fang L, Monroe F, Weiser Novak S, Kirk L, Schiavon CR, Yu SB, Zhang T, Wu M, Kastner K, Latif AA, Lin Z, Shaw A, Kubota Y, Mendenhall J, Zhang Z, Pekkurnaz G, Harris K, Howard J, Manor U (2021) Deep learning-based point-scanning super-resolution imaging. Nature Methods, 18:406-416. (PDF; New study shows how deep-learning technology can improve brain imaging)
     
  • Abbott LF, Bock DD, Callaway EM, Denk W, Dulac C, Fairhall AL, Fiete I, Harris KM, Helmstaedter M, Jain V, Kasthuri N, LeCun Y, Lichtman JW, Littlewood PB, Luo L, Maunsell JHR, Reid RC, Rosen BR, Rubin GM, Sejnowski TJ, Seung HS, Svoboda K, Tank DW, Tsao D, Van Essen DC (2020) The Mind of a Mouse. Cell, 182:1372-1376. (PDF)
     
  • Ostrovskaya OI, Cao G, Eroglu C, Harris KM (2020) Developmental onset of enduring long‐term potentiation in mouse hippocampus. Hippocampus, 30(9): 1-15. PMCID: PMC8359899. (PDF)
     
  • Harris KM (2020) Structural LTP: from synaptogenesis to regulated synapse enlargement and clustering. Current Opinion in Neurobiology, 63:189-197. (PDF)
     
  • Harris KM (2020) Synaptic Odyssey. J Neurosci, 40(1):61-80. PMCID: PMC6939477. (PDF)
     
  • Kuwajima M, Ostrovskaya OI, Cao G, Weisberg SA, Harris KM, Zemelman BV (2020) Ultrastructure of light-activated axons following optogenetic stimulation to produce late-phase long-term potentiation. PLoS One, 15(1):e0226797. (PDF)
     
  • Leopold DA, Strick PL, Bassett DS, Bruno RM, Cuntz H, Harris KM, Oberlander M, Raichle ME (2020) Ch 9: Functional Architecture of the Cerebral Cortex. The Neocortex, Singer W, Sejnowski TJ, Rakic P (eds.). (PDF)
     
  • Kuwajima M, Ostrovskaya OI, Cao G, Weisberg SA, Harris KM, Zemelman BV (2019) Ultrastructure of light-activated axons following optogenetic stimulation to produce late-phase long-term potentiation. bioRxiv, doi.org/10.1101/799890. (PDF)
     
  • Ostrovskaya OI, Cao G, Eroglu C, Harris KM (2019) Developmental onset of enduring long-term potentiation in mouse hippocampus. bioRxiv, doi.org/10.1101/787192. (PDF)
     
  • Kulik Y, Watson DJ, Cao G, Kuwajima M, Harris KM (2019) Structural plasticity of dendritic secretory compartments during LTP-induced synaptogenesis. eLife, 8:e46356. (PDF, shared data)
     
  • Fang L, Monroe F, Novak SW, Kirk L, Schiavon C, Yu SB, Zhang T, Wu M, Kastner K, Kubota Y, Zhang Z, Pekkurnaz G, Mendenhall J, Harris K, Howard J, Manor U (2019) Deep Learning-Based Point-Scanning Super-Resolution Imaging. bioRxiv, doi.org/10.1101/740548. (PDF)
     
  • Litvina E, Adams A, Barth A, Bruchez M, Carson J, Chung J, Dupre K, Frank L, Gates K, Harris K, Joo H, Lichtman J, Ramos K, Sejnowski T, Trimmer J, White S, and Koroshetz W (2019) BRAIN Initiative: Cutting-edge tools and resources for the community. Journal of Neuroscience, 39(42):8275-8284. (PDF)
     
  • Chirillo MA, Waters MS, Lindsey LF, Bourne JN, Harris KM (2019) Local resources of polyribosomes and SER promote synapse enlargement and spine clustering after long-term potentiation in adult rat hippocampus. Scientific Reports, 9(1):3861. PMCID: PMC6405867. (PDF)
     
  • Ostroff LE, Watson DJ, Cao G, Parker PH, Smith H, Harris KM (2018) Shifting patterns of polyribosome accumulation at synapses over the course of hippocampal long-term potentiation. Hippocampus, 28:416-430. PMCID: PMC5992065. (PDF)
     
  • Bromer C, Bartol TM, Bowden JB, Hubbard DD, Hanka DC, Gonzalez PV, Kuwajima M, Mendenhall JM, Parker PH, Abraham WC, Sejnowski TJ, Harris KM (2018) Long-term potentiation expands information content of hippocampal dentate gyrus synapses. PNAS, 115(10):E2410-E2418. PMCID: PMC5877922. (PDF; Supplemental)
     
  • Smith HL, Bourne JN, Cao G, Chirillo MA, Ostroff LE, Watson DJ, and Harris KM (2016) Mitochondrial support of persistent presynaptic vesicle mobilization with age-dependent synaptic growth after LTP. eLife, 5:e15275. PMCID: PMC5235352. (PDF)
     
  • Watson DJ, Ostroff L, Cao G, Parker PH, Smith H, Harris KM (2016) LTP enhances synaptogenesis in the developing hippocampus. Hippocampus, 26(5):560-76. PMCID: PMC4811749. (PDF with supplemental)
     
  • Kirk LM and Harris KM (2016) Dendritic Spines. In: eLS. John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0000093.pub3
     
  • Harris KM and Spacek J (2016) Dendrite Structure. In: Stuart et al. (Eds) Dendrites. 3rd Edition, Oxford University Press, Oxford UK. (PDF: book version; manuscript)
     
  • Chirillo M, Bourne J, Lindsey L, Harris K (2015) Complexity of dendritic SER increases at enlarging synapses during LTP. bioRxiv doi: 10.1101/015974. (PDF)
     
  • Bartol TM, Bromer C, Kinney JP, Chirillo MA, Bourne JN, Harris KM, Sejnowski TJ (2015) Nanoconnectomic upper bound on the variability of synaptic plasticity. eLife, 4:e10778. PMCID: PMC4737657. (PDF; Salk Press Release) 
     
  • Bartol TM, Keller DX, Kinney JP, Bajaj CL, Harris KM, Sejnowski TJ, Kennedy MB (2015) Computational reconstitution of spine calcium transients from individual proteins. Front. Synaptic Neurosci. 7:17. doi: 10.3389/fnsyn.2015.00017. PMCID: PMC4595661. (PDF)
     
  • Bailey CH, Kandel ER, Harris KM (2015) Structural Components of Synaptic Plasticity and Memory Consolidation. Cold Spring Harb Perspect Biol. Jul 1;7(7):a021758. (PDF)
     
  • Harris KM, Spacek J, Bell ME, Parker PH, Lindsey LF, Baden AD, Vogelstein JT, Burns R (2015) A resource from 3D electron microscopy of hippocampal neuropil for user training and tool development. Sci Data Sep 1;2:150046. PMCID: PMC4555877. (PDF; Tables; Shared Data)


2010-2014

  • Bell ME, Bourne JN, Chirillo MA, Mendenhall JM, Kuwajima M, Harris KM (2014) Dynamics of nascent and active zone ultrastructure as synapses enlarge during long-term potentiation in mature hippocampus. J Comp Neurol, 522(17):3861-84. PMCID: PMC4167938. (2MB PDF)
  • Cao G, Harris KM (2014) Augmenting saturated LTP by broadly spaced episodes of theta-burst stimulation in hippocampal area CA1 of adult rats and mice. J Neurophysiol, 112(8):1916-24. PMCID: PMC4200006. (2MB PDF)
  • Bourne JN, Chirillo MA, Harris KM (2013) Presynaptic ultrastructural plasticity along CA3->CA1 axons during LTP in mature hippocampus. J Comp Neurol, 521(17):3898-912. PMCID: PMC3838200. (1MB PDF)
  • Edwards J, Daniel E, Kinney J, Bartol T, Sejnowski T, Johnston D, Harris K, Bajaj C (2013) VolRoverN: Enhancing surface and volumetric reconstruction for realistic dynamical simulation of cellular and subcellular function. Neuroinformatics, 12(2):277-89. PMCID: PMC4033674. (1MB PDF)
  • Kuwajima M, Mendenhall JM, Lindsey LF, Harris KM (2013) Automated Transmission-Mode Scanning Electron Microscopy (tSEM) for Large Volume Analysis at Nanoscale Resolution. PLoS One, 8(3):e59573. PMCID: PMC3608656. (9MB PDF)
  • Kinney JP, Spacek J, Bartol TM, Bajaj CL, Harris KM, Sejnowski TJ (2013) Extracellular sheets and tunnels modulate glutamate diffusion in hippocampal neuropil. J. Comp. Neurology, 521:448-464. PMCID: PMC3540825. (8MB PDF) (Shared data) 
  • Kuwajima M, Mendenhall JM, Harris KM (2013) Large-Volume Reconstruction of Brain Tissue from High-Resolution Serial Section Images Acquired by SEM-Based Scanning Transmission Electron Microscopy. Methods Mol Biol (Nanoimaging: Methods and Protocols), 950:253-73. (1MB PDF)
  • Kuwajima M, Spacek J, Harris KM (2013) Beyond counts and shapes: Studying pathology of dendritic spines in the context of the surrounding neuropil through serial section electron microscopy. Neuroscience, 251:75-89. PMCID: PMC3535574. (2MB PDF)
  • Harris KM, Weinberg RJ (2012) Ultrastructure of Synapses in the Mammalian Brain. Cold Spring Harb Perspect Biol., 4(5). (2.4MB PDF)
  • Cao G, Harris KM (2012) Developmental regulation of the late phase of long-term potentiation (L-LTP) and metaplasticity in hippocampal area CA1 of the rat. J Neurophysiol., 107(3):902-12. PMCID: PMC3289468. (2.5MB PDF)
  • Cui-Wang T, Hanus C, Cui T, Helton T, Bourne J, Watson D, Harris KM, Ehlers MD (2012) Local zones of endoplasmic reticulum complexity confine cargo in neuronal dendrites. Cell, 148(1-2):309-21. PMCID: PMC3266556. (PDF with supplemental material; supplementary movies)
    • Commentary on Cui-Wang et al.: Lewis S (2012) Cellular neurophysiology: ER cargo confinement influences dendritic plasticity. Nat Rev Neurosci, 13(3):152-3. (300KB PDF)
  • Bowden JB, Abraham WC, Harris KM (2012) Differential effects of strain, circadian cycle, and stimulation pattern on LTP and concurrent LTD in the dentate gyrus of freely moving rats. Hippocampus, 22(6):1363-1370. PMCID: PMC3292688. (700KB PDF)
  • Bourne JN, Harris KM (2011) Nanoscale analysis of structural synaptic plasticity. Curr Opin Neurobiol., 22(3):372-82. PMCID: PMC3292623. (3MB PDF)
  • Bourne JN, Harris KM (2011) Coordination of size and number of excitatory and inhibitory synapses results in a balanced structural plasticity along mature hippocampal CA1 dendrites during LTP. Hippocampus, 21(4):354-73. PMCID: PMC2891364. (1.8MB PDF)
  • Shi B, Bourne J, Harris KM (2011) SynapticDB, effective web-based management and sharing of data from serial section electron microscopy. Neuroinformatics, 9:39–57. PMCID: PMC3063557. (3MB PDF)
  • Ivannikov MV, Harris KM, Macleod GT (2010) Mitochondria: enigmatic stewards of the synaptic vesicle reserve pool. Frontiers in Synaptic Neuroscience, 2:145. PMCID: PMC3059713. (800KB PDF)
  • Mishchenko Y, Hu T, Spacek J, Mendenhall J, Harris KM, Chklovskii DB (2010) Ultrastructural analysis of hippocampal neuropil from the connectomics perspective. Neuron, 67:1009-1020. (2MB PDF)
  • Kuwajima M, Harris KM (2010) GABAA receptor diversity revealed in freeze-fracture replica (Commentary on Kasugai et al.). European Journal of Neuroscience, 32:1866-1867. NIHMSID: NIHMS248941. (90KB PDF)
  • Witcher MR, Park YD, Lee MR, Sharma S, Harris KM, Kirov SA (2010) Three-dimensional relationships between perisynaptic astroglia and human hippocampal synapses. Glia, 58(5):572-87. PMCID: PMC2845925. (1.4MB PDF)
  • Jain V, Bollmann B, Richardson M, Berger DR, Helmstaedter MN, Briggman KL, Denk W, Bowden JB, Mendenhall JM, Abraham WC, Harris KM, Kasthuri N, Hayworth KJ, Schalek R, Tapia JC, Lichtman JW, Seung HS (2010) Boundary learning by optimization with topological constraints. Proceedings of the IEEE 23rd Conference on Computer Vision and Pattern Recognition (CVPR '10), 2488-2495. (PDF)
  • Jacobs G, Claiborne B, Harris KM (2010) Reconstruction of Neuronal Morphology. In: De Schutter (Ed) Computational Modeling Methods for Neuroscientists. The MIT Press, Cambridge. (3MB PDF)


2005-2009

  • Routh BN, Johnston D, Harris KM, and Chitwood RA (2009) Anatomical and Electrophysiological Comparison of CA1 Pyramidal Neurons of the Rat and Mouse. J Neurophysiol, 102: 2288–2302. PMCID: PMC2775381. (3MB PDF)
     
  • Bourne JN and Harris KM (2009) Ultrastructural Analysis of Spine Plasticity. Encyclopedia of Neuroscience, 4th Edition, Squire LR (Editor in Chief), Elsevier, New York, pp. 11-17. (PDF)
  • Fiala JC, Spacek J and Harris KM (2008) Dendrite Structure. In: Stuart et al. (Eds) Dendrites. 2nd Edition, Oxford University Press, Oxford UK. (12MB PDF)  
  • Harris, KM (2008) Diversity in synapse structure and composition. In: Hell & Ehlers (Eds) Structural and Functional Organization of the Synapse. Springer. (7MB PDF)
  • Bourne JN, Harris KM. (2008) Balancing structure and function at hippocampal dendritic spines. Annu Rev Neurosci. 31:47-67. PMCID: PMC2561948. (0.4MB PDF)
  • Bourne J and Harris KM (2007) Do thin spines learn to be mushroom spines that remember? Curr Opin Neurobiol 17:381-386. (1.5MB PDF)
  • Witcher MR, Kirov SA, and Harris KM (2007) Plasticity of perisynaptic astroglia during synaptogenesis in the mature rat hippocampus. Glia 55:13-23. (0.7MB PDF)
  • Bourne JN, Sorra KE, Hurlburt J, and Harris KM (2007) Polyribosomes are increased in spines of CA1 dendrites 2 h after the induction of LTP in mature rat hippocampal slices. Hippocampus 17:1-4. (0.4MB PDF)
  • Bourne JN, Kirov SA, Sorra KE, and Harris KM (2007) Warmer preparation of hippocampal slices prevents synapse proliferation that might obscure LTP-related structural plasticity. Neuropharmacol 52:55-59. (0.4MB PDF)
     
  • Bourne JN and Harris KM (2007) Dendritic Spines.  Encyclopedia of Life Sciences. 2nd Edition, Macmillan Reference Ltd, London. (PDF)
  • Harris KM, Perry E, Bourne J, Feinberg M, Ostroff L, and Hurlburt J (2006) Uniform serial sectioning for transmission electron microscopy. J Neurosci 26(47):12101-12103. (0.2MB PDF)
  • Park M, Salgado JM, Ostroff L, Helton TD, Robinson CG, Harris KM, and Ehlers M (2006) Plasticity-induced growth of dendritic spines by Exocytic trafficking from recycling endosomes. Neuron 52:817-830. PMCID: PMC1899130. (2.3MB PDF). Commentaries on Park et al.:
    • Kopec C and Malinow R (2006) Matters of size. Science 314(5805):1554-1555. (300KB PDF)
    • Halpain S (2006) They're plastic, but they recycle. Neuron 52:746-748. (60KB PDF)
  • Sorra KE, Mishra A, Kirov SA, and Harris KM (2006) Dense core vesicles resemble active-zone transport vesicles and are diminished following synaptogenesis in mature hippocampal slices. Neuroscience 141:2097-2106. (0.8MB PDF)
  • Petrak LJ, Harris KM and Kirov SA (2005) Synaptogenesis on Mature Hippocampal Dendrites occurs via Filopodia and Immature Spines during Blocked Synaptic Transmission. J. Comp. Neurology 484:183-190. (0.4MB PDF)
  • Fiala JC (2005) Reconstruct: A free editor for serial section microscopy. J Microscopy 218:52-61 (0.3MB PDF)
  • Seid MA, Harris KM and Traniello JFA (2005) Age-related changes in the number and structure of synapses in the lip region of the mushroom bodies in the ant Pheidole dentata.  J Comp Neurol  488:269-277. (0.5MB PDF)


2000-2004

  • Harris KM (2004) Dendritic Spines. Encyclopedia of Neuroscience, 3rd Edition. G. Adelman and B. Smith Editors. (0.4MB PDF).
  • Spacek J and Harris KM (2004) Trans-endocytosis via Spinules in Adult Rat Hippocampus. J Neuroscience 24(17):4233-41; and featured in This week in the journal. (1.2MB PDF)
  • Kirov SA, Petrak LJ, Fiala JC, Harris KM (2004) Dendritic spines disappear with chilling but proliferate excessively upon rewarming of mature hippocampus. Neuroscience 127(1):69-80. (0.8MB PDF)
  • Kirov SA, Goddard CA, and Harris KM (2004) Age-dependence in the homeostatic upregulation of hippocampal dendritic spine number during blocked synaptic transmission.  Neuropharmacology 47(5):640-8. (0.4MB PDF)
  • Fiala JC, Kirov SA, Feinberg MD, Petrak LJ, Goddard CA, George P and Harris KM (2003) Timing of Neuronal and Glial Ultrastructure Disruption During Brain Slice Preparation and Recovery During Incubation In Vitro. J Comp Neurol. 465(1):90-103.  (1MB PDF)
  • Harris KM, Fiala JC, Ostroff L. (2003) Structural changes at dendritic spine synapses during long-term potentiation. Philos Trans R Soc Lond B Biol Sci. 358:745-8. PMCID: PMC1693146. (2.8MB PDF)
     
  • Gardner D, Toga AW, Ascoli GA, Beatty JT, Brinkley JF, Dale AM, Fox PT, Gardner EP, George JS, Goddard N, Harris KM, Herskovits EH, Hines ML, Jacobs GA, Jacobs RE, Jones EG, Kennedy DN, Kimberg DY, Mazziotta JC, Miller PL, Mori S, Mountain DC, Reiss AL, Rosen GD, Rottenberg DA, Shepherd GM, Smalheiser NR, Smith KP, Strachan T, Van Essen DC, Williams RW, Wong ST (2003) Towards effective and rewarding data sharing. Neuroinformatics, 1(3):289-95. (PDF)
  • Henze DA, McMahon DB, Harris KM, Barrionuevo G (2002) Giant miniature EPSCs at the hippocampal mossy fiber to CA3 pyramidal cell synapse are monoquantal. J Neurophysiol. 87(1):15-29. (0.5MB PDF)
  • Fiala JC, Harris KM (2002) Computer-based alignment and reconstruction of serial sections. Microscopy and Analysis. USA Edition. 52:5-7. (3.5MB PDF)
  • Cooney JR, Hurlburt JL, Selig DK, Harris KM, Fiala JC (2002) Endosomal compartments serve multiple hippocampal dendritic spines from a widespread rather than a local store of recycling membrane. J Neurosci 22:2215-2224. (0.7MB PDF)
  • Fiala JC, Allwardt B, Harris KM (2002) Dendritic spines do not split during hippocampus LTP or maturation. Nat Neurosci 5:297-298. (0.3MB PDF)
  • Fiala JC, Spacek J, Harris KM (2002) Dendritic spine pathology: Cause or consequence of neurological disorders? Brain Research Reviews 39:29-54. (2MB PDF)
     
  • Harris KM (2002) Dendritic Spines. Encyclopedia of Life Sciences. Macmillian Reference Ltd, London. (PDF)
  • Ostroff LE, Fiala JC, Allwardt B, Harris KM (2002) Polyribosomes redistribute from dendritic shafts into spines with enlarged synapses during LTP in developing rat hippocampal slices. Neuron 35:535-545. (0.5MB PDF)
  • Fiala JC, Harris KM (2001) Extending unbiased stereology of brain ultrastructure to three-dimensional volumes. Journal of the American Medical Informatics Association. 8(1):1-16. PMCID: PMC134588. (1.4MB PDF)
  • Fiala JC, Harris KM (2001) Cylindrical diameters method for calibrating section thickness in serial electron microscopy. J Microscopy 202(3):468-472. (0.2MB PDF)
  • Feinberg MD, Szumowski KM, Harris KM (2001) Microwave fixation of rat hippocampal slices. In: RT Giberson, RS DeMaree Jr. (eds.) Microwave Techniques and Protocols. Humana Press: Totowa, New Jersey. pp. 75-88. (2MB PDF)
  • Xu-Friedman MA, Harris KM, Regehr WG (2001) Three-dimensional comparison of ultrastructural characteristics at depressing and facilitating synapses onto cerebellar Purkinje cells. J Neuroscience 21(17):6666-6672. (2MB PDF)
  • Sorra KE, Harris KM (2000) Overview on the structure, composition, function, development, and plasticity of hippocampal dendritic spines. Hippocampus 10(5):501-511. (0.6MB PDF)
     
  • Eichenbaum H and Harris KM (2000) Toying with memory in the hippocampus. Nature Neuroscience 3:205-206. (0.1MB PDF)


1995-1999

  • Kirov SA, Sorra KE, Harris KM (1999) Slices have more synapses than perfusion-fixed hippocampus from both young and mature rats. J Neuroscience 19(8):2876-2886. (1.4MB PDF)
  • Harris KM (1999) Structure, development, and plasticity of dendritic spines. Current Opinion in Neurobiology 9:343-348. (1.3MB PDF)
  • Fiala JC, Harris KM (1999) Dendrite Structure. In: G Stuart, N Spruston, M Häusser, (eds.) Dendrites. Oxford University Press: Oxford UK. (2.6MB PDF)
  • Ventura R, Harris KM (1999) Three-dimensional relationships between hippocampal synapses and astrocytes. J Neuroscience 19(16):6897-6906. (0.9MB PDF)
  • Kirov SA, Harris KM (1999) Dendrites are more spiny on mature hippocampal neurons when synapses are inactivated. Nature Neuroscience 2(10):878-883. (0.6MB PDF)
  • Harris, KM (1999) Calcium from internal stores modifies dendritic spine shape. Proc. Natl. Acad. Sci. 96:12213-12215. PMCID: PMC34250. (0.4MB PDF)
  • Spacek J, Harris KM (1998) Three-dimensional organization of cell adhesion junctions at synapses and dendritic spines in area CA1 of the rat hippocampus. J. Comp. Neurol. 393:58-68.  (0.9MB PDF)
  • Fiala JC, Feinberg M, Popov V, Harris KM (1998) Synaptogenesis via dendritic filopodia in developing hippocampal area CA1. J. Neurosci. 18:8900-8911. (1.1MB PDF)
  • Shepherd GMG, Harris KM (1998) Three-dimensional structure and composition of CA3-->CA1 axons in rat hippocampal slices: implications for presynaptic connectivity and compartmentalization. J. Neurosci. 18:8300-8310. (1MB PDF)
  • Sorra KE, Fiala JC, Harris KM (1998) Critical assessment of the involvement of perforations, spinules, and spine branching in hippocampal synapse formation. J. Comp. Neurol. 398:225-240. (1.6MB PDF)
  • Sorra KE, Harris KM (1998) Stability in synapse number and size at 2 hr after long-term potentiation in hippocampal area CA1. J. Neurosci. 18:658-671. (1.4MB PDF)
  • Finkbeiner S, Tavazoie SF, Maloratsky A, Jacobs KM, Harris KM, Greenberg ME (1997) CREB: a major mediator of neuronal neurotrophin responses. Neuron 19:1031-1047.  (0.5MB PDF)
  • Ouyang Y, Kantor D, Harris KM, Schuman EM, Kennedy MB (1997) Visualization of the distribution of autophosphorylated Calcium/ Calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus. J. Neurosci. 17:5416-5427. (1.6MB PDF)
  • Spacek J, Harris KM (1997) Three-dimensional organization of smooth endoplasmic reticulum in hippocampal CA1 dendrites and dendritic spines of the immature and mature rat. J. Neurosci. 17:190-203. (2.6MB PDF)
  • Harris KM (1997) Dendritic Spines. Encyclopedia of Neuroscience, 2nd Edition. G. Adelman and B. Smith Editors. (2.8MB PDF)
  • Harris KM (1995) How multiple-synapse boutons could preserve input specificity during an interneuronal spread of LTP. Trends. Neurosci. 18:365-369. (2.6MB PDF)
  • Harris KM, Sultan P (1995) Variation in number, location, and size of synaptic vesicles provides an anatomical basis for the non-uniform probability of release at hippocampal CA1 synapses. J. Neuropharmacology 34:1387-1395. (3.3MB PDF)


1990-1994

  • Carlbom I, Terzopoulos D, Harris KM (1994) Computer-assisted registration, segmentation, and 3D reconstruction from images of neuronal tissue sections. IEEE Transaction of Medical Imaging 13(2):351. (11MB PDF)  
  • Harris KM, Kater SB (1994) Dendritic spines: Cellular specializations imparting both stability and flexibility to synaptic function. Annu. Rev. Neurosci.17:341-371. (2MB PDF)
  • Harris KM (1994) Serial electron microscopy as an alternative or complement to confocal microscopy for the study of synapses and dendritic spines in the central nervous system. In: Three-dimensional confocal microscopy: volume investigation of biological specimens (Stevens JK, Mills LR, Trogadis JE eds), pp 421-445. New York: Academic Press, Inc. (5MB PDF)
  • Lisman J, Harris KM (1994) Who's been nibbling on my PSD: Is it LTD? J. Physiol. (Paris) 88:193-195. (3.7MB PDF)
  • Harris KM, Rosenberg PA (1993) Localization of synapses in rat cortical cultures. Neuroscience 53(2):495-508. (4.4MB PDF)
  • Jackson PS, Suppes T, Harris KM (1993) Stereotypical changes in the pattern and duration of long-term potentiation at postnatal days 11 and 15 in the rat hippocampus. J. Neurophysiol. 70:1412-1419. (1.6MB PDF)
  • Lisman J, Harris KM (1993) Quantal analysis and synaptic anatomy - integrating two views of hippocampal plasticity. Trends Neurosci. 16:141-147. (PDF)
  • Sorra KE, Harris KM (1993) Occurrence and three-dimensional structure of multiple synapses between individual radiatum axons and their target pyramidal cells in hippocampal area CA1. J. Neurosci. 13:3736-3748.  (4.8MB PDF)
  • Chicurel ME, Harris KM (1992) Three-dimensional analysis of the structure and composition of CA3 branched dendritic spines and their synaptic relationships with mossy fiber boutons in the rat hippocampus. J. Comp. Neurol. 325:169-182. (4.2MB PDF)
  • Harris KM, Jensen FE, Tsao B (1992) Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: Implications for the maturation of synaptic physiology and long-term potentiation. J. Neurosci. 12:2685-2705. (6.8MB PDF)
  • Carlbom I, Terzopoulos D. and Harris KM. (1991) Reconstructing and visualizing models of neuronal dendrites. In: Patrikalakis, NM (Ed.) Scientific Visualization of Physical Phenomena. Springer-Verlag, New York. (4.2MB PDF)


1985-1989

  • Harris KM, Jensen FE, Tsao B (1989) Ultrastructure, development, and plasticity of dendritic spine synapses in area CA1 of the rat hippocampus: Extending our vision with serial electron microscopy and three-dimensional analyses. In: The Hippocampus - New Vistas, Neurology and Neurobiology Volume 52 (Chan-Palay V, Kohler C eds), pp 33-52. New York: Alan R. Liss. (3.1MB PDF)
  • Harris KM, Stevens JK (1989) Dendritic spines of CA1 pyramidal cells in the rat hippocampus: serial electron microscopy with reference to their biophysical characteristics. J. Neurosci. 9:2982-2997. (1.9MB PDF)
  • Jensen FE, Harris KM (1989) Preservation of neuronal ultrastructure in hippocampal slices using rapid microwave-enhanced fixation. J. Neurosci. Methods. 29:217-230. (4.2MB PDF)
  • Teyler TJ, Perkins AT4, Harris KM (1989) The development of long-term potentiation in hippocampus and neocortex. Neuropsychologia. 27:31-39.  (6MB PDF)
  • Harris KM, Stevens JK (1988) Dendritic spines of rat cerebellar Purkinje cells: Serial electron microscopy with reference to their biophysical characteristics. J. Neurosci. 8:4455-4469. (2.2MB PDF)
  • Harris KM, Stevens JK (1988) Study of dendritic spines by serial electron microscopy and three-dimensional reconstructions. In: Intrinsic determinants of neuronal form and function. Neurology and Neurobiology Volume 37 (Lasek RJ, Black MM eds), pp 179-199. New York: Alan R. Liss. (2.7MB PDF)
  • Harris KM, Landis DM (1986) Membrane structure at synaptic junctions in area CA1 of the rat hippocampus. Neurosci. 19:857-872. (3.8MB PDF)
  • Harris KM, Marshall PE, Landis DM (1985) Ultrastructural study of cholecystokinin-immunoreactive cells and processes in area CA1 of the rat hippocampus. J. Comp. Neurol. 233:147-158. (4MB PDF)


1980-1984

  • Harris KM, Teyler TJ (1984) Developmental onset of long-term potentiation in area CA1 of the rat hippocampus. J. Physiol. (Lond.) 346:27-48. PMCID: PMC1199482. (3MB PDF)
  • Harris KM, Teyler TJ (1983) Age differences in a circadian influence on hippocampal LTP. Brain Res. 261:69-73. (0.6MB PDF)
  • Harris KM, Teyler TJ (1983) Evidence for late development of inhibition in area CA1 of the rat hippocampus. Brain Res. 268:339-343. (0.6MB PDF)
  • Harris KM, Cruce WLR, Greenough WT, Teyler TJ (1980) A Golgi impregnation technique for thin brain slices maintained in vitro. J. Neurosci. Methods. 2:363-371. (2.5MB PDF)
  • Harris KM (1980) Relationships between dendrite and spine neck diameters in freeze-fractured rat hippocampal formation. Biol. Bull. 159:470-471. (1.7MB PDF)